Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709149 | 0.90 | FYN (0.46) | FYNMAPTPOLBTDP1 | |
| SCHEMBL7711838 | 0.86 | SMN1; SMN2 (0.50) | TP53JAK1KDM4ENPC1RAB9A | |
| SCHEMBL7711818 | 0.83 | ALDH1A1 (0.42) | TP53KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7708546 | 0.83 | NPC1 (0.42) | TP53KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7705877 | 0.83 | SMN1; SMN2 (0.41) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7708772 | 0.77 | SMN1; SMN2 (0.38) | FYNKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7485272 | 0.75 | ADORA2A (0.57) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7708412 | 0.75 | ADORA2A (0.54) | TP53KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7433615 | 0.74 | KDM4E (0.39) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7711746 | 0.73 | KDM4E (0.41) | TP53KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |