Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711838 | 0.92 | SMN1; SMN2 (0.50) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7711818 | 0.89 | ALDH1A1 (0.42) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7705877 | 0.89 | SMN1; SMN2 (0.41) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7708772 | 0.89 | SMN1; SMN2 (0.38) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7705875 | 0.83 | TP53 (0.42) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7433615 | 0.79 | KDM4E (0.39) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7709149 | 0.77 | FYN (0.46) | MAPTBRAF | |
| SCHEMBL7708784 | 0.73 | SMN1; SMN2 (0.54) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7708503 | 0.72 | NPC1 (0.53) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7708891 | 0.71 | KDM4E (0.49) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |