Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | PPM1B | O75688 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447972 | 1.00 | CES2 (0.56) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL2447976 | 1.00 | CES2 (0.56) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL2447975 | 1.00 | CES2 (0.56) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL8193371 | 0.82 | CES2 (0.53) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL13286850 | 0.80 | PPM1B (0.56) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL9310364 | 0.77 | TDP1 (0.52) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL3727933 | 0.76 | TDP1 (0.50) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL8191270 | 0.76 | PPM1B (0.52) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL8183690 | 0.76 | PPM1B (0.52) | CES2PPM1BTDP1SLC6A2SLC6A3 | |
| SCHEMBL7700089 | 0.75 | TDP1 (0.53) | TDP1SLC6A2SLC6A3KMT2ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6353122-B1 | IN CYCLOHEXANONE WITH POTASSIUM PEROXYMONOSULFATE AND SUBSEQUENT REARRANGEMENT TO PROVIDE THE CORRESPONDING CYCLOBUTANONE | BRISTOL-MYERS SQUIBB COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0433897-B1 | Process for preparing an optically active cyclobutane nucleoside | SQUIBB & SONS INC (US) | 1997-10-01 | — | — | EP | disclosed |
| EP-0736533-A1 | Intermediates and process for the preparation of an antiviral agent | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5525726-A | Process for the preparation of an antiviral agent | E. R. SQUIBB & SONS, INC. (US) | 1996-06-11 | — | — | US | disclosed |
| US-5344962-A | Intermediates in the synthesis of an optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1994-09-06 | — | — | US | disclosed |
| US-5306837-A | Intermediates for an optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0572209-A2 | Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol | E.R. SQUIBB & SONS, INC. (US) | 1993-12-01 | — | — | EP | disclosed |
| US-5256806-A | Intermediates for the preparation of optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5237095-A | Process for the preparation of an antiviral agent | E. R. SQUIBB & SONS, INC. (US) | 1993-08-17 | — | — | US | disclosed |
| US-5233076-A | Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1993-08-03 | — | — | US | disclosed |
| US-5218142-A | Process for the preparation of an antiviral agent | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5198583-A | Optically active cyclobutane nucleoside and intermediates, therefor | E. R. SQUIBB & SONS, INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5185463-A | PROCESS FOR THE PREPARATION OF AN ANTIVIRAL AGENT | E. R. SQUIBB & SONS, INC. (US) | 1993-02-09 | — | — | US | disclosed |
| US-H1142-H | Antiviral agent against herpes and varicella-zoster viruses | E. R. SQUIBB & SONS, INC. | 1993-02-02 | — | — | US | disclosed |
| US-5064961-A | PROCESS FOR PREPARING AN OPTICALLY ACTIVE CYCLOBUTANE NUCLEOSIDE | E. R. SQUIBB & SONS, INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0433897-A2 | Process for preparing an optically active cyclobutane nucleoside | E.R. SQUIBB & SONS, INC. (US) | 1991-06-26 | — | — | EP | disclosed |