Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | PPM1B | O75688 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727933 | 0.86 | TDP1 (0.50) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL13286850 | 0.84 | PPM1B (0.56) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL11323408 | 0.84 | CES2 (0.46) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL2447975 | 0.82 | CES2 (0.56) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL2447972 | 0.82 | CES2 (0.56) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL7705887 | 0.82 | CES2 (0.56) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL2447976 | 0.82 | CES2 (0.56) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL9310364 | 0.81 | TDP1 (0.52) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL15046638 | 0.80 | CHRNB2 (0.50) | CES2PPM1BTDP1CHRNB2CHRNA5 | |
| SCHEMBL29413708 | 0.79 | CES2 (0.46) | CES2PPM1BTDP1CHRNB2CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121431-A | VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS AND HEPATITIS B VIRUS | MEDIVIR AB (SE) | 2000-09-19 | — | — | US | disclosed |
| US-5952500-A | VIRICIDES CAN BE USED IN THERAPEUTIC AND PROPHYLACTIC TREATMENT OF THE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS), INFECTIONS OF HUMAN IMMUNE DEFICIENCY VIRUSES, HEPATITIS B VIRUS, HERPES VIRUSES AND CANCER | MEDIVIR AB (SE) | 1999-09-14 | — | — | US | disclosed |
| US-5747473-A | L-nucleoside analogues and pharmaceutical compositions | MEDIVIR AB (SE) | 1998-05-05 | — | — | US | disclosed |
| US-5473063-A | Reacting 2,3-epoxy-butanediol/1,4-/(having protected hydroxyl groups) with an alpha allylic nucleophile yields 2-hydroxy-3-allyl-1,4-butanediol, then oxidatively cleaving the double bond, cyclization, halogenation, acetylation or oxyalkylation | MEDIVIR AB (SE) | 1995-12-05 | — | — | US | disclosed |
| EP-0554274-A1 | NUCLEOSIDE DERIVATIVES | Medivir Aktiebolag (SE) | 1993-08-11 | — | — | EP | disclosed |
| WO-1992006102-A1 | NUCLEOSIDE DERIVATIVES | MEDIVIR AB (SE) | 1992-04-16 | — | — | WO | disclosed |