Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 11/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708412 | 0.90 | ADORA2A (0.54) | ADORA2AKITFLT3RXFP1SMN1; SMN2 | |
| SCHEMBL7705969 | 0.88 | MAPT (0.52) | FYNRXFP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7708431 | 0.82 | POLB (0.43) | FYNRXFP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7709146 | 0.81 | ADORA2A (0.52) | ADORA2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7481320 | 0.81 | ADORA2A (0.54) | ADORA2AFYNFLT3SMN1; SMN2NPC1 | |
| SCHEMBL7484739 | 0.80 | ADORA2A (0.52) | ADORA2A | |
| SCHEMBL7705871 | 0.80 | FYN (0.55) | ADORA2AFYNSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7481934 | 0.80 | ADORA2A (0.54) | ADORA2AFYNRXFP1SMN1; SMN2NPC1 | |
| SCHEMBL7703127 | 0.79 | ADORA2A (0.52) | ADORA2ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL7708837 | 0.79 | GRM5 (0.52) | ADORA2ASMN1; SMN2NPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |