Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 9/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484739 | 0.85 | ADORA2A (0.52) | — | |
| SCHEMBL7705969 | 0.85 | MAPT (0.52) | POLBTP53MAPTFYNHSD17B1 | |
| SCHEMBL7481934 | 0.85 | ADORA2A (0.54) | POLBTP53MAPTFYNHSD17B1 | |
| SCHEMBL7705893 | 0.82 | ADORA2A (0.52) | TP53MAPTFYNKDM4ERXFP1 | |
| SCHEMBL7708828 | 0.81 | RAB9A (0.51) | TP53MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7703234 | 0.81 | ADORA2A (0.38) | MAP4K4ALDH1A1SMN1; SMN2 | |
| SCHEMBL7711711 | 0.80 | ALDH1A1 (0.44) | TP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7708391 | 0.80 | ADORA2A (0.45) | MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7705871 | 0.80 | FYN (0.55) | TP53MAPTFYNNQO2KDM4E | |
| SCHEMBL7705951 | 0.79 | BACE1 (0.40) | MAP4K4ALDH1A1SMN1; SMN2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |