Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705893 | 0.88 | ADORA2A (0.52) | MAPTTP53FYNKDM4ERXFP1 | |
| SCHEMBL7705871 | 0.86 | FYN (0.55) | MAPTTP53FYNKDM4ESMN1; SMN2 | |
| SCHEMBL7484739 | 0.86 | ADORA2A (0.52) | MAPK1CYP2C19 | |
| SCHEMBL7708431 | 0.85 | POLB (0.43) | MAPTPOLBTP53FYNKDM4E | |
| SCHEMBL7481934 | 0.85 | ADORA2A (0.54) | MAPTPOLBTP53FYNKDM4E | |
| SCHEMBL7708830 | 0.84 | MAPT (0.46) | MAPTPOLBTP53KDM4ENPSR1 | |
| SCHEMBL7709149 | 0.82 | FYN (0.46) | MAPTPOLBFYN | |
| SCHEMBL7423524 | 0.79 | ALDH1A1 (0.53) | MAPTPOLBTP53KDM4ESMN1; SMN2 | |
| SCHEMBL7709122 | 0.78 | MAOA (0.47) | MAPTKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL6868100 | 0.78 | ADORA2A (0.44) | MAPTPOLBTP53KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |