Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | PRCP | P42785 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705677 | 0.87 | HHAT (0.37) | TRPM8PRCPADRA1DADRA1AADRA1B | |
| SCHEMBL7705532 | 0.87 | HHAT (0.37) | TRPM8PRCPADRA1DADRA1AADRA1B | |
| SCHEMBL7705731 | 0.84 | TRPM8 (0.36) | TRPM8PRCPCYP19A1ADRA1DADRA1A | |
| SCHEMBL7705909 | 0.82 | CYP19A1 (0.44) | TRPM8PRCPCYP19A1CYP11B2KDM4E | |
| SCHEMBL7698083 | 0.82 | FNTA (0.34) | PRCP | |
| SCHEMBL7698116 | 0.81 | TRPM8 (0.45) | TRPM8PRCPCYP19A1CYP11B2 | |
| SCHEMBL7705565 | 0.81 | CHRM3 (0.35) | GAAPRCPKDM4EADRA1DADRA1A | |
| SCHEMBL7703410 | 0.80 | PRCP (0.35) | TRPM8PRCPCYP11B2ADRA1DADRA1A | |
| SCHEMBL7703888 | 0.80 | PRCP (0.39) | TRPM8PRCPADRA1DADRA1AADRA1B | |
| SCHEMBL7704881 | 0.78 | CYP19A1 (0.44) | GAACYP19A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |