SCHEMBL7706345

SCHEMBL7706345

Cc1ccc(CCN2CCC(c3nc4cccc(C(N)=O)c4[nH]3)C2)cc1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 16/20 0.61
PARP2 Q9UGN5 3/20 0.50
HRH1 P35367 2/20 0.41
HTR1A P08908 1/20 0.41
ADRA2C P18825 1/20 0.41
DRD1 P21728 1/20 0.41
DRD4 P21917 1/20 0.41
HRH2 P25021 1/20 0.41
HTR1B P28222 1/20 0.41
HTR2C P28335 1/20 0.41
SLC6A4 P31645 1/20 0.41
HTR7 P34969 1/20 0.41
OPRM1 P35372 1/20 0.41
HTR2B P41595 1/20 0.41
HTR5A P47898 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7706397 0.96 PARP1 (0.55) PARP1PARP2HRH1HTR1AADRA2C
SCHEMBL7705471 0.91 PARP1 (0.62) PARP1PARP2
SCHEMBL7706351 0.91 PARP1 (0.61) PARP1PARP2DRD4
SCHEMBL7708486 0.90 PARP1 (0.58) PARP1PARP2HRH1HTR1AHTR2C
SCHEMBL5619951 0.88 PARP1 (0.56) PARP1PARP2HRH1OPRM1
SCHEMBL5621241 0.88 PARP1 (0.58) PARP1PARP2HRH1DRD4
SCHEMBL7706349 0.88 PARP1 (0.61) PARP1PARP2HRH3
SCHEMBL7705626 0.87 PARP1 (0.56) PARP1PARP2
SCHEMBL7706365 0.87 PARP1 (0.57) PARP1PARP2HTR1AHTR7HTR2B
SCHEMBL7708440 0.87 PARP1 (0.61) PARP1PARP2DRD4HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6448271-B1 SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY BASF AKTIENGESELLSCHAFT (DE) 2002-09-10 US disclosed