SCHEMBL7706397

SCHEMBL7706397

Cc1ccc(CCN2CCC(c3nc4cccc(C(N)=O)c4[nH]3)CC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 14/20 0.55
PARP2 Q9UGN5 2/20 0.54
ALDH1A1 P00352 2/20 0.44
HTR1A P08908 1/20 0.42
ADRA2C P18825 1/20 0.42
DRD1 P21728 1/20 0.42
DRD4 P21917 1/20 0.42
HRH2 P25021 1/20 0.42
HTR1B P28222 1/20 0.42
HTR2C P28335 1/20 0.42
SLC6A4 P31645 1/20 0.42
HTR7 P34969 1/20 0.42
HRH1 P35367 1/20 0.42
OPRM1 P35372 1/20 0.42
HTR2B P41595 1/20 0.42
HTR5A P47898 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
USP2 O75604 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7706345 0.96 PARP1 (0.61) PARP1PARP2ALDH1A1HTR1AADRA2C
SCHEMBL7705626 0.91 PARP1 (0.56) PARP1PARP2
SCHEMBL7705624 0.90 PARP1 (0.55) PARP1PARP2HTR1AADRA2CDRD1
SCHEMBL7706352 0.90 PARP1 (0.55) PARP1PARP2HTR2CHTR7HTR2B
SCHEMBL7700398 0.90 PARP1 (0.55) PARP1PARP2ALDH1A1DRD4HTR2B
SCHEMBL7702685 0.90 PARP1 (0.55) PARP1PARP2
SCHEMBL7706364 0.90 PARP1 (0.53) PARP1PARP2HTR1AHTR2CHTR7
SCHEMBL5621735 0.88 PARP1 (0.51) PARP1PARP2HRH1
SCHEMBL7702702 0.88 PARP1 (0.55) PARP1PARP2
SCHEMBL5620912 0.88 PARP1 (0.53) PARP1PARP2DRD4HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6448271-B1 SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY BASF AKTIENGESELLSCHAFT (DE) 2002-09-10 US disclosed