SCHEMBL7706424

SCHEMBL7706424

O=[C]OCCN1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.42
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
PSMB1 P20618 2/20 0.40
PSMB5 P28074 2/20 0.40
PSMB2 P49721 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP1A2 P05177 1/20 0.38
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
KCNH2 Q12809 1/20 0.38
NPC1 O15118 1/20 0.38
TSHR P16473 1/20 0.37
KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1998371 0.98 HRH3 (0.39) HRH3ALDH1A1POLBMAPTPSMB1
SCHEMBL5251321 0.87 HRH3 (0.50) HRH3CYP1A2MAPK1SMN1; SMN2KCNH2
SCHEMBL8561716 0.85 HRH3 (0.54) HRH3MAPTL3MBTL1KCNH2
SCHEMBL5946007 0.84 HRH3 (0.46) HRH3ALDH1A1MAPTCYP1A2MAPK1
SCHEMBL5946046 0.80 ALDH1A1 (0.37) HRH3ALDH1A1MEN1KMT2ANPC1
SCHEMBL290317 0.78 GLA (0.42) ALDH1A1MEN1KMT2ASMN1; SMN2NPC1
SCHEMBL9534058 0.78 KDM1A (0.32)
SCHEMBL5540209 0.78 POLB (0.45) HRH3ALDH1A1POLBMAPTMEN1
SCHEMBL2104339 0.76 LMNA (0.36) HRH3ALDH1A1POLBMAPTL3MBTL1
SCHEMBL17135438 0.74 HRH3 (0.39) HRH3MAPTPSMB1PSMB5PSMB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0173933-B1 1,6-NAPHTHYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENT CONTAINING THEM GÖDECKE AKTIENGESELLSCHAFT (DE) 1989-11-29 EP claimed
EP-1259478-A1 COVALENT DERIVATIVES OF ALKANOLAMIDES OF MONOCARBOXYLIC AND DICARBOXYLIC ACIDS FUNCTIONALLY ACTIVE ON THE CB2 CANNABINOID RECEPTOR Innovet Italia S.r.l. (IT) 2002-11-27 EP disclosed
WO-2001004083-A1 COVALENT DERIVATIVES OF ALKANOLAMIDES OF MONOCARBOXYLIC AND DICARBOXYLIC ACIDS FUNCTIONALLY ACTIVE ON THE CB2 CANNABINOID RECEPTOR INNOVET ITALIA S.R.L. (IT) 2001-01-18 WO disclosed
US-5968688-A RESINS AND DYES FOR COLOR FILTERS NIPPON SHOKUBAI CO., LTD. (JP) 1999-10-19 US disclosed
EP-0833203-A1 Color filter grade photosensitive resin coloring composition, and color filter using the same NIPPON SHOKUBAI CO., LTD. (JP) 1998-04-01 EP disclosed
WO-1991011448-A1 THERAPEUTIC AGENTS THE BOOTS COMPANY PLC (GB) 1991-08-08 WO disclosed
US-4853393-A HYPOTENSIVE AGENTS, ANTICOAGULANTS CIBA-GEIGY CORPORATION (US) 1989-08-01 US disclosed
EP-0171217-B1 FUSED-RING HETEROCYCLIC COMPOUNDS A PROCESS FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE SANKYO COMPANY LIMITED (JP) 1989-05-03 EP disclosed
US-4808603-A HYPOTENSIVE, VASODILATION AGENTS CIBA-GEIGY CORPORATION (US) 1989-02-28 US disclosed
US-4735959-A HYPOGLYCEMIC AGENTS DR. KARL THOMAE GMBH (DE) 1988-04-05 US disclosed
US-4616002-A HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1986-10-07 US disclosed
EP-0174654-A2 Carbonyl derivatives CIBA-GEIGY AG (CH) 1986-03-19 EP disclosed
EP-0174653-A2 Phenylalkyl derivatives CIBA-GEIGY AG (CH) 1986-03-19 EP disclosed
EP-0171217-A2 Fused-ring heterocyclic compounds a process for their production and their pharmaceutical use SANKYO COMPANY LIMITED (JP) 1986-02-12 EP disclosed
EP-0145956-A1 Composés amidés CIBA-GEIGY AG (CH) 1985-06-26 EP disclosed
US-4497808-A N-Oxide compounds useful in the treatment of cardiovascular ailments CIBA-GEIGY CORPORATION (US) 1985-02-05 US disclosed
EP-0111455-A2 Unsaturated lactones CIBA-GEIGY AG (CH) 1984-06-20 EP disclosed
EP-0111453-A1 Amide derivatives CIBA-GEIGY AG (CH) 1984-06-20 EP disclosed
EP-0099017-A2 Phenyl-acetic-acid derivatives, their preparation and pharmaceutical compostions containing them Dr. Karl Thomae GmbH (DE) 1984-01-25 EP disclosed
EP-0083315-A2 Pyridyl-N-oxides, processes for their preparation and pharmaceutical compositions containing them CIBA-GEIGY AG (CH) 1983-07-06 EP disclosed