Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PDE2A | O00408 | 2/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819172 | 0.88 | TP53 (0.64) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL7712315 | 0.81 | GAA (1.00) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL7712463 | 0.79 | L3MBTL1 (0.70) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL14369601 | 0.76 | KDM4E (0.59) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL17731474 | 0.76 | KDM4E (0.75) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL7712318 | 0.75 | GAA (0.57) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL17731346 | 0.75 | PDE2A (1.00) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL7706435 | 0.75 | TSHR (0.51) | GAAHPGDTSHRALDH1A1LMNA | |
| SCHEMBL7272830 | 0.74 | GAA (0.52) | GAAHPGDTSHRALDH1A1KDM4E | |
| SCHEMBL18997819 | 0.74 | F2 (0.62) | HPGDTSHRALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369065-B1 | CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | UCB S.A. (BE) | 2002-04-09 | — | — | US | claimed |
| US-6369065-B1 | CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | UCB S.A. (BE) | 2002-04-09 | — | — | US | disclosed |