SCHEMBL7706817

SCHEMBL7706817

CCCCCC(OC(=O)CC(C)=O)Oc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 3/20 0.33
ALDH2 P05091 2/20 0.33
CNR2 P34972 3/20 0.32
ENPP2 Q13822 1/20 0.32
TLR8 Q9NR97 1/20 0.32
NPC1 O15118 2/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
ITGB1 P05556 1/20 0.31
ITGA4 P13612 1/20 0.31
CNR1 P21554 1/20 0.30
FGFR1 P11362 1/20 0.30
FGFR2 P21802 1/20 0.30
FGFR3 P22607 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709554 0.84 MAPT (0.34) NPC1RAB9AKMT2AEGLN1LMNA
SCHEMBL7709567 0.81 TLR8 (0.36) PLK1ALDH2CNR2ENPP2TLR8
SCHEMBL1068828 0.81 TLR8 (0.35) PLK1ALDH2CNR2TLR8NPC1
SCHEMBL10253638 0.81 CNR1 (0.36) PLK1ALDH2CNR2TLR8NPC1
SCHEMBL25373352 0.80 ALDH2 (0.42) PLK1ALDH2CNR2ENPP2TLR8
SCHEMBL26629793 0.80 ALDH2 (0.47) PLK1ALDH2
SCHEMBL7744803 0.79 CNR2 (0.36) PLK1CNR2
SCHEMBL8029936 0.78 CNR2 (0.33) PLK1ALDH2CNR2ENPP2TLR8
SCHEMBL8036063 0.78 CNR2 (0.33) PLK1ALDH2CNR2ENPP2TLR8
SCHEMBL8030165 0.78 CNR2 (0.33) PLK1ALDH2CNR2ENPP2TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355708-B2 USEFUL IN STABILIZING POLYMERS AND OTHER MATERIALS FROM DEGRADATION BY ENVIRONMENTAL FORCES SUCH AS ACTINIC RADIATION (ULTRAVIOLET LIGHT), OXIDATION, MOISTURE, ATMOSPHERIC POLLUTANTS CIBA SPECIALTY CHEMICALS CORPORATION 2002-03-12 US disclosed
US-20010031866-A1 Novel trisaryl-1,3,5-triazine ultraviolet light absorbers GUPTA RAM BABOO (US) 2001-10-18 US disclosed
US-6242597-B1 STABILIZERS WITH A BONDABLE GROUP HAVING AN ACTIVE (ACIDIC) HYDROGEN; MIGRATION BETWEEN POLYMER LAYERS IS REDUCED CIBA SPECIALTY CHEMICALS CORPORATION 2001-06-05 US disclosed
EP-1032563-A1 TRISARYL-1,3,5-TRIAZINE ULTRAVIOLET LIGHT ABSORBERS CYTEC TECHNOLOGY CORP. (US) 2000-09-06 EP disclosed
WO-1999026934-A1 TRISARYL-1,3,5-TRIAZINE ULTRAVIOLET LIGHT ABSORBERS CYTEC TECHNOLOGY CORP. (US) 1999-06-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010031866-A1 Novel trisaryl-1,3,5-triazine ultraviolet light absorbers ERCC5, XRCC5, ERCC1 PLK1 2600/4885ALDH2 1561/4885CNR2 2205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.