Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.68 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.68 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeinone SCHEMBL101725 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL13154678 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL13633530 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL12137788 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL100655 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL14192923 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL3107493 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL29375985 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL13952981 | 0.99 | OPRM1 (1.00) | OPRM1OPRK1OPRD1MRGPRX2PDE4D | |
| Codeinone SCHEMBL11533410 | 0.94 | OPRM1 (0.91) | OPRM1OPRK1OPRD1MRGPRX2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365742-B1 | THEBAINE AND (N-METHYL)ANALOGUES CONTAINING A DIENOL ESTER OR ETHER FROM MORPHOLINE, CODEINONE OR ANALOGUES HAVING AN ALPHA-BETA UNSATURATED KETONE VIA A NOVEL ALKOXYLATED INTERMEDIATE | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2002-04-02 | — | — | US | disclosed |
| US-6090943-A | Preparation of opiates, intermediates and uses of salts | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2000-07-18 | — | — | US | disclosed |
| EP-0889045-A1 | Process for the production of thebaine and analogues thereof, as well as intermediate products therefor | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1999-01-07 | — | — | EP | disclosed |