Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Codeinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.91 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.67 |
| ▸ | OPRK1 known ✓ | P41145 | 7/20 | 0.64 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.64 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeinone SCHEMBL101725 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL13154678 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL29375985 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL100655 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL3107493 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL14192923 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL13952981 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL12137788 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL13633530 | 0.95 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2PDE4D | |
| Codeinone SCHEMBL7707098 | 0.94 | OPRM1 (0.98) | OPRM1OPRD1OPRK1MRGPRX2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140687-A | Process for the preparation of 8-halodihydrocodeinone hydrohalides and codeine | MACFARIAN SMITH LIMITED (GB) | 1979-02-20 | — | — | US | disclosed |