Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 5/20 | 0.33 |
| ▸ | CDK8 | P49336 | 5/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563026 | 0.86 | CCNC (0.40) | PDE4BPDE4DPDE4APDE4CCCNC | |
| SCHEMBL2560821 | 0.86 | HPGD (0.41) | PDE4BPDE4DPDE4APDE4CCCNC | |
| SCHEMBL2562773 | 0.86 | HPGD (0.41) | PDE4BPDE4DPDE4APDE4CCCNC | |
| SCHEMBL2556065 | 0.84 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2562731 | 0.83 | KDM4E (0.39) | CCNCCDK8MEN1KMT2ALMNA | |
| SCHEMBL7709222 | 0.77 | SMN1; SMN2 (0.41) | PDE4BPDE4DPDE4APDE4CCCNC | |
| SCHEMBL2562661 | 0.75 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2556731 | 0.73 | CCNC (0.42) | CCNCCDK8MEN1KMT2ALMNA | |
| SCHEMBL2562008 | 0.73 | CCNC (0.42) | CCNCCDK8CA12CA9 | |
| SCHEMBL74217 | 0.72 | PDE4B (0.63) | PDE4BPDE4DPDE4APDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |