Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | YAP1 | P46937 | 1/20 | 0.31 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710218 | 0.87 | HTR2C (0.33) | POLBTRPM8ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7711223 | 0.81 | PARP1 (0.38) | HTTGAANPSR1POLBTRPM8 | |
| SCHEMBL7089254 | 0.81 | HTT (0.35) | HTTGAANPSR1POLBTRPM8 | |
| SCHEMBL7708174 | 0.77 | GAA (0.37) | HTTGAANPSR1POLBTRPM8 | |
| Hydrochloric Acid SCHEMBL7708365 | 0.76 | — | — | |
| SCHEMBL7704961 | 0.73 | HDAC3 (0.33) | POLBTRPM8ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5188384 | 0.72 | LMNA (0.31) | HTTNPSR1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5468708 | 0.70 | — | — | |
| SCHEMBL6302740 | 0.70 | HDAC3 (0.43) | GAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5476931 | 0.70 | HDAC1 (0.36) | ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |