Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710216 | 0.88 | HSD17B10 (0.35) | POLBTRPM8ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7711223 | 0.82 | PARP1 (0.38) | GAAHTTNPSR1POLBTRPM8 | |
| SCHEMBL7089254 | 0.82 | HTT (0.35) | GAAHTTNPSR1POLBTRPM8 | |
| SCHEMBL7708337 | 0.78 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL7708180 | 0.77 | HTT (0.34) | GAAHTTNPSR1POLBTRPM8 | |
| SCHEMBL7710851 | 0.73 | AAK1 (0.31) | — | |
| SCHEMBL6995053 | 0.72 | POLB (0.34) | POLBTRPM8ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7704910 | 0.72 | HDAC1 (0.45) | NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7704892 | 0.72 | — | — | |
| SCHEMBL7711553 | 0.71 | CYP2C19 (0.32) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |