Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704890 | 0.89 | CTSK (0.32) | CTSSCTSK | |
| SCHEMBL7710991 | 0.88 | CTSK (0.32) | ALDH1A1CTSSCTSK | |
| SCHEMBL7710849 | 0.85 | MAPK10 (0.31) | MAPK10ACE2 | |
| SCHEMBL7708011 | 0.83 | LATS1 (0.34) | MAPK10 | |
| SCHEMBL7711551 | 0.83 | NPC1 (0.33) | MAPK10SMN1; SMN2 | |
| SCHEMBL7711067 | 0.81 | NAMPT (0.36) | ALDH1A1 | |
| SCHEMBL7705086 | 0.81 | NPSR1 (0.35) | MAPK10GAA | |
| SCHEMBL7711428 | 0.80 | PARP1 (0.39) | ALDH1A1MAPK10GAA | |
| SCHEMBL7089637 | 0.80 | ALDH1A1 (0.32) | ALDH1A1MAPK10 | |
| SCHEMBL7713259 | 0.78 | USP2 (0.39) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |