Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP9 | P14780 | 4/20 | 0.35 |
| ▸ | MMP8 | P22894 | 4/20 | 0.35 |
| ▸ | MMP13 | P45452 | 4/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711186 | 0.92 | NR3C2 (0.41) | SLC2A1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7711366 | 0.89 | HDAC1 (0.37) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL7708189 | 0.89 | HDAC3 (0.37) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL7704910 | 0.88 | HDAC1 (0.45) | HDAC3HDAC1HDAC2NCOR2ALDH1A1 | |
| SCHEMBL7704965 | 0.87 | HDAC3 (0.36) | NR1D1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7708353 | 0.87 | GRM2 (0.37) | NR1D1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7713435 | 0.86 | HDAC1 (0.34) | HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7710748 | 0.86 | CA2 (0.35) | HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7711328 | 0.86 | HDAC3 (0.35) | HDAC3HDAC1HDAC2NCOR2MAPT | |
| SCHEMBL7704946 | 0.86 | ALDH1A1 (0.38) | NR1D1SLC2A1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |