Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714255 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2HRH4HRH1MAPTHTR3B | |
| SCHEMBL7708441 | 0.85 | TSHR (0.57) | SMN1; SMN2HRH4HRH1MAPTHTR3A | |
| SCHEMBL7712401 | 0.84 | HPGD (0.50) | MAPT | |
| SCHEMBL7714603 | 0.84 | HRH4 (0.57) | HRH4HRH1HTR6 | |
| SCHEMBL7716622 | 0.82 | MAPT (0.43) | HRH4MAPTHTR6 | |
| SCHEMBL7714106 | 0.82 | HRH4 (0.51) | SMN1; SMN2HRH4HRH1MAPTHTR3B | |
| SCHEMBL7712449 | 0.77 | HTR6 (0.56) | HRH4HTR6 | |
| SCHEMBL1491746 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2HRH4MAPTHTR3BHTR3A | |
| SCHEMBL7708590 | 0.73 | MAPT (0.47) | SMN1; SMN2MAPT | |
| SCHEMBL7714282 | 0.73 | HRH4 (0.56) | HRH4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |