Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708590 | 0.88 | MAPT (0.47) | HPGDMAPTGAAPKMALDH1A1 | |
| SCHEMBL7708464 | 0.85 | KDM4E (0.54) | HPGDMAPTGAAHTR2CHTR2B | |
| SCHEMBL7708466 | 0.84 | SMN1; SMN2 (0.55) | MAPT | |
| SCHEMBL7714543 | 0.84 | PIK3CA (0.55) | HPGDGAAPKMHTR2CHTR2B | |
| SCHEMBL7716622 | 0.82 | MAPT (0.43) | MAPTMAPK1PIK3CAHRH3 | |
| SCHEMBL7714116 | 0.77 | DHFR (0.50) | PKMAKT1PIK3CAKDM4ECYP11B2 | |
| SCHEMBL7711748 | 0.74 | ALDH1A1 (0.54) | HPGDGAAALDH1A1TSHRHSD17B10 | |
| SCHEMBL1935491 | 0.74 | KDM4E (0.46) | MAPTGAAALDH1A1TSHRALOX15 | |
| SCHEMBL7708477 | 0.73 | MGMT (0.48) | HPGDGAAPKMALDH1A1TSHR | |
| SCHEMBL7711799 | 0.73 | OGA (0.47) | HPGDGAAPKMALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |