Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714574 | 0.85 | DHFR (0.41) | AURKACDC7PLK4CHEK1PDPK1 | |
| SCHEMBL7708466 | 0.82 | SMN1; SMN2 (0.55) | MAPTHTR6HRH4 | |
| SCHEMBL7712401 | 0.82 | HPGD (0.50) | MAPTPIK3CAMAPK1HRH3 | |
| SCHEMBL7712353 | 0.78 | RPS6KB1 (0.41) | HTR6RPS6KB1MAPK12PTPN11 | |
| SCHEMBL7716662 | 0.74 | DCLK1 (0.45) | MAPTPIK3CAAURKALCKFGFR1 | |
| SCHEMBL7714521 | 0.74 | SMO (0.46) | MAPTHTR6PIK3CASMOEGFR | |
| SCHEMBL7714288 | 0.73 | DHFR (0.39) | — | |
| SCHEMBL1400767 | 0.73 | HCRTR2 (0.47) | MAPTPIK3CASMOPIM1STK3 | |
| SCHEMBL13649032 | 0.73 | ABL1 (0.56) | MAPK1 | |
| SCHEMBL7708590 | 0.71 | MAPT (0.47) | MAPTRAB9AMAPK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |