Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 14/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714688 | 0.84 | PTGS2 (0.41) | SRD5A1PTGS1PTGS2NOTUM | |
| SCHEMBL7708916 | 0.76 | TRPV1 (0.33) | SRD5A1NOTUMMCHR1 | |
| SCHEMBL7708921 | 0.76 | TRPV1 (0.32) | SRD5A1NOTUMMCHR1HSD17B3 | |
| SCHEMBL7708985 | 0.75 | PTGS2 (0.44) | SRD5A1PTGS1PTGS2NOTUM | |
| SCHEMBL8484026 | 0.72 | SRD5A1 (0.50) | SRD5A1SRD5A2NOTUMMCHR1HSD17B3 | |
| SCHEMBL4735384 | 0.70 | SRD5A1 (0.45) | SRD5A1SRD5A2NOTUM | |
| SCHEMBL8197924 | 0.70 | SRD5A1 (0.41) | SRD5A1SRD5A2PTGS1PTGS2NOTUM | |
| SCHEMBL24076749 | 0.69 | PTGS2 (0.43) | PTGS1PTGS2NOTUM | |
| SCHEMBL12332825 | 0.68 | HTR2C (0.62) | SRD5A1SRD5A2HTR2AHTR2CHTR2B | |
| SCHEMBL13948529 | 0.68 | HTR2C (0.62) | SRD5A1SRD5A2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |