Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 12/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714916 | 0.89 | ADRB3 (0.40) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL7714914 | 0.89 | ADRB3 (0.40) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL7708901 | 0.80 | SLC6A2 (0.39) | ADRB3ADRB1ADRB2GLAAOC3 | |
| SCHEMBL8586756 | 0.78 | ADRB3 (0.41) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL8586761 | 0.78 | ADRB3 (0.41) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL9270684 | 0.78 | MAPT (0.44) | ADRB3ADRB1ADRB2 | |
| SCHEMBL9270681 | 0.78 | MAPT (0.44) | ADRB3ADRB1ADRB2 | |
| SCHEMBL9063602 | 0.78 | AOC3 (0.43) | MEN1KMT2AAOC3IDO1 | |
| SCHEMBL7716904 | 0.77 | AOC3 (0.36) | ADRB3ADRB1ADRB2MEN1KMT2A | |
| SCHEMBL7069969 | 0.76 | ADRB3 (0.35) | ADRB3ADRB1ADRB2GLAAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865421-B1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS | GLAXO GROUP LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| US-6048872-A | DIETETICS; ANTIDIABETIC AGENTS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO WELLCOME INC. (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0865421-A1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS | GLAXO GROUP LIMITED (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021665-A1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS | GLAXO GROUP LIMITED (GB) | 1997-06-19 | — | — | WO | disclosed |
| WO-1997021666-A1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS | GLAXO GROUP LIMITED (GB) | 1997-06-19 | — | — | WO | disclosed |