Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9889372 | 0.84 | MAPT (0.58) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL29029672 | 0.83 | SMN1; SMN2 (0.48) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7714554 | 0.83 | NPC1 (0.50) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL27496358 | 0.82 | SMN1; SMN2 (0.47) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL12091718 | 0.81 | SMN1; SMN2 (0.46) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL29029675 | 0.79 | SMN1; SMN2 (0.44) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7708924 | 0.79 | SMN1; SMN2 (0.44) | NPC1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL9258457 | 0.79 | LMNA (0.50) | NPC1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL28568347 | 0.78 | KMT2A (0.66) | NPC1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL28573269 | 0.78 | KMT2A (0.44) | NPC1MEN1KMT2ASMN1; SMN2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |