Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | CPA3 | P15088 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP9 | P14780 | 2/20 | 0.45 |
| ▸ | MMP12 | P39900 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6821357 | 0.91 | CPA3 (0.56) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL9889372 | 0.91 | MAPT (0.58) | NPC1MAPTMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL11517845 | 0.89 | MAPT (0.56) | NPC1MAPTMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL2761665 | 0.89 | MAPT (0.56) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL12475390 | 0.84 | MMP2 (0.52) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL27992180 | 0.84 | MMP2 (0.59) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL1828579 | 0.84 | MAPT (0.54) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL7708927 | 0.83 | NPC1 (0.48) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL28770741 | 0.83 | MMP2 (0.58) | NPC1MAPTMAPK1HTTRAB9A | |
| SCHEMBL9390878 | 0.83 | RAB9A (0.58) | NPC1MAPTMAPK1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |