SCHEMBL7709034

SCHEMBL7709034

Cc1cncn1CC(Cc1ccc(C(=O)N[C@@H](CCC(N)=O)C(=O)O)c(-c2ccccc2)c1)c1ccc(F)cc1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 6/20 0.43
FNTB P49356 6/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7708863 0.90 FNTA (0.55) FNTAFNTB
SCHEMBL8224557 0.89 QPCT (0.36) FNTAFNTB
SCHEMBL7247326 0.84 CYP11B1 (0.39) FNTAFNTB
SCHEMBL7245868 0.83 QPCT (0.41) FNTAFNTB
SCHEMBL8210036 0.82 DCAF1 (0.38) FNTAFNTB
SCHEMBL7703311 0.79 FNTA (0.41) FNTAFNTB
SCHEMBL7703319 0.79 FNTA (0.41) FNTAFNTB
SCHEMBL7659533 0.73 CYP51A1 (0.46) FNTAFNTB
SCHEMBL8212007 0.72 FNTA (0.49) FNTAFNTB
SCHEMBL7703414 0.71 FNTA (0.45) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6414145-B1 TREATING CANCER AND NEUROFIBROMATOSIS ZENECA LIMITED (GB) 2002-07-02 US disclosed
EP-0975603-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ZENECA LIMITED (GB) 2000-02-02 EP disclosed
WO-1998032741-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ZENECA LIMITED (GB) 1998-07-30 WO disclosed