SCHEMBL8212007

SCHEMBL8212007

CSCC[C@H](NC(=O)c1ccc(CC(Cc2ncc(C)[nH]2)c2ccc(F)cc2)cc1-c1ccccc1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 6/20 0.49
FNTB P49356 6/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8210036 0.89 DCAF1 (0.38) FNTAFNTB
SCHEMBL8210369 0.84 BRS3 (0.46)
SCHEMBL7708863 0.82 FNTA (0.55) FNTAFNTB
SCHEMBL8199862 0.80 FNTA (0.51) FNTAFNTB
SCHEMBL8197818 0.76 FNTA (0.48) FNTAFNTB
SCHEMBL8592425 0.75 FNTA (0.68) FNTAFNTB
SCHEMBL7916459 0.75 FNTA (0.67) FNTAFNTB
SCHEMBL7916449 0.75 FNTA (0.67) FNTAFNTB
SCHEMBL8207053 0.74 FNTA (0.52) FNTAFNTB
SCHEMBL7636670 0.74 FNTA (0.64) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975603-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ZENECA LIMITED (GB) 2000-02-02 EP disclosed
WO-1998032741-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ZENECA LIMITED (GB) 1998-07-30 WO disclosed