Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.54 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708740 | 0.89 | ADORA2A (0.57) | ADORA2AFYNALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7708573 | 0.88 | ADORA2A (0.52) | ADORA2AALDH1A1HPGDL3MBTL1MEN1 | |
| SCHEMBL7709012 | 0.85 | ADORA2A (0.49) | ADORA2ACCNA2CDK2CDK5DYRK1A | |
| SCHEMBL7708503 | 0.85 | NPC1 (0.53) | ADORA2ACDK5CDK5R1FYNALDH1A1 | |
| SCHEMBL7432234 | 0.85 | ADORA2A (0.56) | ADORA2AFYNALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7705947 | 0.83 | ADORA2A (0.54) | ADORA2AALDH1A1HPGDL3MBTL1MEN1 | |
| SCHEMBL7709122 | 0.82 | MAOA (0.47) | ADORA2AATAD2ALDH1A1HPGDMEN1 | |
| SCHEMBL7705871 | 0.81 | FYN (0.55) | ADORA2ADYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL7705971 | 0.80 | ADORA2A (0.51) | ADORA2AALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7711729 | 0.79 | ADORA2A (0.52) | ADORA2AALDH1A1HPGDL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |