Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 4/20 | 0.55 |
| ▸ | CTSK | P43235 | 3/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 7/20 | 0.50 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193288 | 0.85 | CTSS (0.64) | CTSSCTSKRENALDH1A1MEN1 | |
| SCHEMBL31291804 | 0.82 | CTSK (0.65) | CA2CTSSCTSKKLK5BACE1 | |
| SCHEMBL11105884 | 0.81 | ACE (0.61) | CA2CTSSCTSKKLK5BACE1 | |
| SCHEMBL23975809 | 0.80 | CTSS (0.61) | CA2CTSSCTSKKLK5KLK7 | |
| SCHEMBL7414154 | 0.80 | CTSS (0.61) | CA2CTSSCTSKKLK5KLK7 | |
| SCHEMBL7414151 | 0.80 | CTSS (0.61) | CA2CTSSCTSKKLK5KLK7 | |
| SCHEMBL8211102 | 0.80 | KLK7 (0.56) | CA2CTSSCTSKKLK5KLK7 | |
| SCHEMBL6619713 | 0.80 | KLK7 (0.58) | CA2CTSSCTSKKLK5KLK7 | |
| SCHEMBL6619716 | 0.80 | KLK7 (0.58) | CA2CTSSCTSKKLK5KLK7 | |
| SCHEMBL12873043 | 0.79 | KLK7 (0.65) | CA2CTSSCTSKKLK5KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |