Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.64 |
| ▸ | CTSK | P43235 | 9/20 | 0.64 |
| ▸ | CTSB | P07858 | 4/20 | 0.64 |
| ▸ | CTSL | P07711 | 2/20 | 0.64 |
| ▸ | BCL2 | P10415 | 1/20 | 0.61 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11979695 | 0.89 | CTSS (0.63) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL1164315 | 0.89 | CTSS (0.63) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL17624777 | 0.89 | CTSS (0.55) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL8000628 | 0.87 | CTSS (0.65) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL8611600 | 0.86 | BCL2 (0.76) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL7709249 | 0.85 | CA2 (0.56) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL6494733 | 0.83 | CA1 (0.67) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL6163823 | 0.82 | CTSS (0.73) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL8951298 | 0.82 | CTSS (0.73) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL6163323 | 0.82 | CTSS (0.73) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265173-A1 | SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES | ZYMEWORKS BC INC. (CA) | 2023-08-24 | — | — | US | disclosed |
| US-11560422-B2 | Sulfonamide-containing linkage systems for drug conjugates | ZYMEWORKS INC. | 2023-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265173-A1 | SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES | MPST, TPST2, SULT1A1 | CTSS 877/4885CTSK 2901/4885CTSB 2251/4885 |
| US-11560422-B2 | Sulfonamide-containing linkage systems for drug conjugates | MPST, TPST2, SULT1A1 | CTSS 877/4885CTSK 2901/4885CTSB 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.