Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TXNRD1 | Q16881 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12120523 | 0.78 | TXNRD1 (0.47) | MAPTMAPK1RAB9ANPSR1S1PR4 | |
| SCHEMBL230859 | 0.78 | RELA (0.59) | PDE10AMAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL22119735 | 0.78 | PDE10A (0.59) | PDE10AMAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL27959562 | 0.78 | PDE10A (0.59) | PDE10AMAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL4822352 | 0.76 | ALDH1A1 (0.65) | MAPTMAPK1RAB9ANPSR1S1PR4 | |
| SCHEMBL26931043 | 0.75 | TXNRD1 (0.56) | MAPTMAPK1RAB9ANPSR1S1PR4 | |
| SCHEMBL1031078 | 0.75 | PDE10A (0.59) | PDE10AMAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL30033520 | 0.75 | PDE10A (0.59) | PDE10AMAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL27930198 | 0.75 | PDE10A (0.59) | PDE10AMAPTMAPK1RAB9ANPSR1 | |
| SCHEMBL9501972 | 0.74 | PDE10A (0.54) | PDE10AMAPTMAPK1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |