Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 4/20 | 0.37 |
| ▸ | FNTB | P49356 | 4/20 | 0.37 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709317 | 1.00 | CA2 (0.39) | CA2CA1MRGPRX4FNTAFNTB | |
| SCHEMBL8227733 | 0.90 | KMT2A (0.33) | CA2CA1 | |
| SCHEMBL8227729 | 0.90 | KMT2A (0.33) | CA2CA1 | |
| SCHEMBL7703338 | 0.89 | FNTA (0.48) | FNTAFNTB | |
| SCHEMBL7703335 | 0.89 | FNTA (0.48) | FNTAFNTB | |
| SCHEMBL7703319 | 0.87 | FNTA (0.41) | FNTAFNTB | |
| SCHEMBL7703311 | 0.87 | FNTA (0.41) | FNTAFNTB | |
| SCHEMBL7706049 | 0.84 | AGTR2 (0.46) | CA2CA1MRGPRX4GPR132 | |
| SCHEMBL7706060 | 0.84 | AGTR2 (0.46) | CA2CA1MRGPRX4GPR132 | |
| SCHEMBL7708946 | 0.81 | TTR (0.39) | MRGPRX4KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |