Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | THPO | P40225 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292409 | 0.85 | SRC (0.47) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL5384052 | 0.70 | CYP3A4 (0.49) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL10686398 | 0.70 | EGFR (0.50) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL7717389 | 0.70 | ALDH1A1 (0.50) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL9640810 | 0.70 | MEN1 (0.45) | SMN1; SMN2LMNAMAPTPMP22CYP2D6 | |
| SCHEMBL659196 | 0.70 | CA12 (0.46) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL13545738 | 0.69 | EGFR (0.41) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL14619522 | 0.69 | EGFR (0.41) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL7471028 | 0.69 | EGFR (0.45) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL7461415 | 0.69 | ALDH1A1 (0.53) | EGFRERBB2ALDH1A1SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0806964-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-08-14 | — | — | EP | disclosed |