Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711197 | 0.89 | MKNK1 (0.37) | MKNK1MKNK2CYP11B1CYP11B2CTSD | |
| SCHEMBL7710836 | 0.88 | ERN1 (0.35) | ERN1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7705399 | 0.85 | BACE1 (0.35) | CTSDBACE1BACE2 | |
| SCHEMBL7715200 | 0.83 | MKNK1 (0.37) | MKNK1MKNK2ERN1MAPK1CYP11B1 | |
| SCHEMBL7711100 | 0.80 | KDR (0.39) | CYP11B1CYP11B2MAPT | |
| SCHEMBL7710613 | 0.79 | CYP11B1 (0.38) | MKNK1MKNK2ERN1MAPK1CYP11B1 | |
| SCHEMBL7710882 | 0.78 | CCNC (0.38) | MAPK1CYP11B1CYP11B2NPC1RAB9A | |
| SCHEMBL7712995 | 0.76 | BACE1 (0.41) | CYP11B1CYP11B2CTSDBACE1BACE2 | |
| SCHEMBL7708344 | 0.74 | ERN1 (0.32) | ERN1BACE1 | |
| SCHEMBL7712670 | 0.72 | ERN1 (0.34) | MKNK1MKNK2ERN1CYP11B2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |