Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709564 | 0.85 | MKNK1 (0.41) | BACE1CTSDBACE2 | |
| SCHEMBL7705409 | 0.85 | BACE1 (0.45) | BACE1CTSDBACE2 | |
| SCHEMBL7705408 | 0.84 | BACE1 (0.35) | BACE1CTSD | |
| SCHEMBL7711197 | 0.81 | MKNK1 (0.37) | BACE1CTSD | |
| SCHEMBL10266284 | 0.69 | BACE1 (0.38) | BACE1CTSD | |
| SCHEMBL7713121 | 0.68 | BACE1 (0.38) | BACE1CTSDBACE2SCN9A | |
| SCHEMBL10266269 | 0.68 | BACE1 (0.37) | BACE1CTSD | |
| SCHEMBL7713517 | 0.67 | CTSD (0.32) | BACE1CTSD | |
| SCHEMBL7708820 | 0.67 | BACE1 (0.33) | BACE1CTSDBACE2 | |
| SCHEMBL7708344 | 0.66 | ERN1 (0.32) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |