Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.36 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706701 | 0.87 | MEN1 (0.47) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL7706694 | 0.81 | MEN1 (0.44) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL8580196 | 0.81 | TDP1 (0.44) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL7709778 | 0.78 | ALDH1A1 (0.45) | MEN1KMT2AMAPK1TDP1ALDH1A1 | |
| SCHEMBL7709788 | 0.77 | KMT2A (0.47) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL7709659 | 0.76 | KMT2A (0.49) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL12415529 | 0.74 | ALDH1A1 (0.66) | MEN1KMT2AALDH1A1NPC1POLB | |
| SCHEMBL7703708 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL7703705 | 0.68 | ALDH1A1 (0.37) | MEN1KMT2AMAPK1CRHBPCRHR2 | |
| SCHEMBL28278092 | 0.67 | MEN1 (0.67) | MEN1KMT2AMAPK1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |