SCHEMBL7709722

SCHEMBL7709722

N#Cc1cc2c3c(cccc3c1N1CC[C@H](NC(=O)O)C1)C(=O)N(O)C2=O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.36
XBP1 P17861 2/20 0.36
HTT P42858 2/20 0.36
HIF1A Q16665 1/20 0.36
POLB P06746 2/20 0.35
MAPT P10636 2/20 0.35
CYP1A2 P05177 1/20 0.35
ERCC1 P07992 1/20 0.35
TSHR P16473 1/20 0.35
ALOX12 P18054 1/20 0.35
FEN1 P39748 1/20 0.35
ERCC4 Q92889 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
USP30 Q70CQ3 5/20 0.34
KMT2A Q03164 2/20 0.33
CTSL P07711 2/20 0.33
CTSB P07858 2/20 0.33
CTSK P43235 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7703898 0.85 CTSL (0.39) USP30CTSLCTSBCTSKRET
SCHEMBL7703732 0.84 POLB (0.39) LMNAXBP1HTTHIF1APOLB
SCHEMBL7703733 0.84 POLB (0.39) LMNAXBP1HTTHIF1APOLB
SCHEMBL7709679 0.79 HTT (0.50) LMNAXBP1HTTHIF1APOLB
SCHEMBL7709658 0.78 HTT (0.52) LMNAXBP1HTTHIF1APOLB
SCHEMBL7703741 0.72 MDM4 (0.39) LMNAXBP1HTTPOLBMAPT
SCHEMBL7703836 0.71 SIGMAR1 (0.37) CTSLCTSBCTSKMTNR1AMTNR1B
SCHEMBL7712299 0.70 POLB (0.40) LMNAXBP1HTTHIF1APOLB
SCHEMBL7709624 0.70 POLB (0.40) LMNAXBP1HTTHIF1APOLB
SCHEMBL25267978 0.68 NOTUM (0.45) USP30MTNR1AMTNR1BNOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362181-B1 BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS WARNER-LAMBERT COMPANY 2002-03-26 US disclosed
US-6177423-B1 N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS WARNER-LAMBERT COMPANY 2001-01-23 US disclosed
EP-0939754-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1999-09-08 EP disclosed
WO-1998019648-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed