Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.45 |
| ▸ | CTSD | P07339 | 9/20 | 0.45 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705408 | 0.88 | BACE1 (0.35) | BACE1CTSDDHODHKCNH2 | |
| SCHEMBL7715226 | 0.88 | BACE1 (0.37) | BACE1CTSDBACE2GSK3BNR3C1 | |
| SCHEMBL7705399 | 0.85 | BACE1 (0.35) | BACE1CTSDBACE2 | |
| SCHEMBL7710882 | 0.79 | CCNC (0.38) | BACE1CTSDDHODH | |
| SCHEMBL7712995 | 0.78 | BACE1 (0.41) | BACE1CTSDBACE2NR3C1KCNH2 | |
| SCHEMBL7713121 | 0.75 | BACE1 (0.38) | BACE1CTSDBACE2GSK3BKCNH2 | |
| SCHEMBL7704729 | 0.75 | MKNK1 (0.39) | BACE1KCNH2 | |
| SCHEMBL7715200 | 0.73 | MKNK1 (0.37) | BACE1KCNH2 | |
| SCHEMBL7712670 | 0.72 | ERN1 (0.34) | BACE1KCNH2 | |
| SCHEMBL7713517 | 0.72 | CTSD (0.32) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |