Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705060 | 0.92 | CA2 (0.35) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7708225 | 0.90 | PARP1 (0.43) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7704907 | 0.89 | HSD17B10 (0.38) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7704945 | 0.89 | HDAC3 (0.44) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7704932 | 0.88 | HDAC3 (0.35) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7711422 | 0.87 | HSD17B10 (0.36) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7708363 | 0.87 | TP53 (0.35) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL6309617 | 0.87 | HDAC1 (0.43) | HDAC3HDAC1HDAC2NCOR2PARP1 | |
| SCHEMBL7710786 | 0.86 | NR1D1 (0.39) | HDAC3HDAC1HDAC2NCOR2HIF1A | |
| SCHEMBL6302990 | 0.85 | PARP1 (0.38) | HDAC3HDAC1HDAC2NCOR2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |