Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708356 | 0.91 | CTSS (0.41) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7704912 | 0.91 | ALDH1A1 (0.45) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7711362 | 0.90 | PTPRB (0.40) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7704904 | 0.90 | CTSL (0.45) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7704877 | 0.90 | CACNA1B (0.40) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7711187 | 0.87 | SIRT2 (0.38) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7711369 | 0.87 | ALDH1A1 (0.37) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7708193 | 0.86 | ALDH1A1 (0.38) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7711460 | 0.86 | ALDH1A1 (0.34) | ALDH1A1NPSR1HPGDHTTHSD17B10 | |
| SCHEMBL7710869 | 0.86 | CTSS (0.42) | ALDH1A1NPSR1HPGDHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |