Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | CASP1 | P29466 | 4/20 | 0.39 |
| ▸ | CASP7 | P55210 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714708 | 0.94 | LMNA (0.46) | MEN1KMT2AHTTLMNAKDM4E | |
| SCHEMBL7714381 | 0.91 | MEN1 (0.49) | MEN1KMT2AHTTLMNAKDM4E | |
| SCHEMBL7716737 | 0.90 | ALDH1A1 (0.48) | MEN1KMT2AHTTLMNAKDM4E | |
| SCHEMBL7712468 | 0.90 | MEN1 (0.51) | MEN1KMT2AHTTLMNAKDM4E | |
| SCHEMBL7716698 | 0.89 | HTR1A (0.46) | KMT2AHTTLMNAKDM4EALDH1A1 | |
| SCHEMBL7714147 | 0.89 | ALDH1A1 (0.44) | MEN1KMT2AHTTLMNAKDM4E | |
| SCHEMBL7714150 | 0.88 | MEN1 (0.61) | MEN1KMT2AHTTNPSR1KDM4E | |
| SCHEMBL7708411 | 0.87 | SRC (0.41) | MEN1KMT2AHTTLMNAKDM4E | |
| SCHEMBL7714712 | 0.86 | KMT2A (0.54) | MEN1KMT2AHTTNPSR1KDM4E | |
| SCHEMBL7708460 | 0.86 | KMT2A (0.54) | MEN1KMT2AHTTNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | claimed |
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |