Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15850325 | 0.78 | MET (0.58) | METALDH1A1ASAH1HPGDSMN1; SMN2 | |
| SCHEMBL23621423 | 0.74 | MET (0.75) | METALDH1A1ASAH1 | |
| SCHEMBL15538697 | 0.73 | MET (0.73) | METALDH1A1ASAH1 | |
| SCHEMBL29019844 | 0.71 | ASAH1 (0.48) | METALDH1A1ASAH1HPGDMAPK1 | |
| SCHEMBL3570523 | 0.69 | MET (0.46) | METALDH1A1ASAH1HPGDMEN1 | |
| SCHEMBL26034746 | 0.68 | ASAH1 (0.48) | METASAH1MEN1KMT2ADAO | |
| SCHEMBL564993 | 0.68 | SMN1; SMN2 (0.46) | METALDH1A1HPGDSMN1; SMN2PLK4 | |
| SCHEMBL3485414 | 0.67 | ALDH1A1 (1.00) | METALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL11827884 | 0.65 | BRD4 (0.47) | METALDH1A1ASAH1SMN1; SMN2PLK4 | |
| SCHEMBL2008746 | 0.64 | KDR (0.68) | ALDH1A1HPGDMAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37623-E1 | PHENYLTHIO AND PHENYLSELENO PYRIMIDINE ANALOGS | el Kouni, Mahmoud H. | 2002-04-02 | — | — | US | disclosed |
| EP-0725641-B1 | NOVEL INHIBITORS OF URIDINE PHOSPHORYLASE (UrdPase) AND DIHYDROURACIL DEHYDROGENASE (DHUDase) | EL KOUNI MAHMOUD H (US) | 2000-12-13 | — | — | EP | disclosed |
| US-5721241-A | PYRIMIDINE COMPOUND USEFUL TO DISRUPT VIRAL, CANCER, FUNGAL, PARASITE OR BACTERIAL REPLICATION AND DIHYDROURACIL DEHYDROGENASE OR URIDINE PHOSPHORYLASE INHIBITORS | el Kouni, Mahmoud H. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0725641-A4 | — | — | 1996-09-04 | — | — | EP | disclosed |
| EP-0725641-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | El Kouni, Mahmoud H. (US) | 1996-08-14 | — | — | EP | disclosed |
| US-5476855-A | Pyrimidine analogs and nucleosides | el Kouni, Mahmoud H. (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1995012400-A1 | NOVEL ENZYME INHIBITORS, THEIR SYNTHESIS, AND METHODS FOR USE | UAB RESEARCH FOUNDATION (US) | 1995-05-11 | — | — | WO | disclosed |