Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738082 | 0.90 | PRF1 (0.54) | PRF1MAPTMAOAMAOBHSD17B10 | |
| SCHEMBL7713036 | 0.86 | HSD17B1 (0.43) | PRF1MAPTMAOAMAOBPLK1 | |
| SCHEMBL7711917 | 0.83 | MAOA (0.45) | PRF1MAPTGAAMAOAMAOB | |
| SCHEMBL14737128 | 0.79 | PRF1 (0.51) | PRF1MAOAMAOBPTPN11ACHE | |
| SCHEMBL7711034 | 0.78 | MAOA (0.41) | PRF1MAOAMAOBPTPN11ACHE | |
| SCHEMBL7713939 | 0.78 | MAOA (0.43) | PRF1MAPTGAAMAOAMAOB | |
| SCHEMBL7714344 | 0.77 | PRF1 (0.53) | PRF1MAOAMAOBPTPN11ACHE | |
| SCHEMBL2589751 | 0.76 | HSD17B1 (0.41) | MAPTGAAACHEKDM4ESMN1; SMN2 | |
| SCHEMBL2594903 | 0.74 | POLQ (0.40) | PRF1MAPTPOLQKDM4E | |
| SCHEMBL14737290 | 0.73 | ALDH1A1 (0.40) | PRF1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |