Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714507 | 0.88 | HRH4 (0.40) | HRH4LMNA | |
| SCHEMBL7712449 | 0.88 | HTR6 (0.56) | HRH4HTR6HRH3KCNH2 | |
| SCHEMBL7712453 | 0.88 | ROCK2 (0.42) | HRH4LMNA | |
| SCHEMBL7712452 | 0.87 | LMNA (0.40) | HRH4LMNA | |
| SCHEMBL7714282 | 0.86 | HRH4 (0.56) | HRH4HTR6HRH3KCNH2 | |
| SCHEMBL7708456 | 0.85 | HRH4 (0.55) | HRH4HTR6HRH3KCNH2 | |
| SCHEMBL7708547 | 0.85 | HTR6 (0.56) | HRH4HTR6HRH3KCNH2 | |
| SCHEMBL7714603 | 0.85 | HRH4 (0.57) | HRH4HTR6HRH3KCNH2 | |
| SCHEMBL7716594 | 0.83 | HTR6 (0.58) | HRH4HTR6 | |
| SCHEMBL7714119 | 0.80 | HRH4 (0.53) | HRH4HTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |