Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL15666483 | 1.00 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL19664202 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL931293 | 0.95 | — | — | |
| Bicarbonate SCHEMBL222993 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL4807761 | 0.95 | CA4 (0.55) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL10379498 | 0.90 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL11403647 | 0.90 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL3395196 | 0.90 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL7983250 | 0.90 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL8421151 | 0.90 | CA4 (0.50) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295191-A1 | A POLYESTER MOLDING COMPRISING A METAL-ORGANIC FRAMEWORK HAVING A LOW OUTGASSING OF VOLATILE ORGANIC COMPOUNDS | BASF SE (DE) | 2023-09-21 | — | — | US | disclosed |
| EP-4188993-A1 | A POLYESTER MOLDING COMPRISING A METAL-ORGANIC FRAMEWORK HAVING A LOW OUTGASSING OF VOLATILE ORGANIC COMPOUNDS | BASF SE (DE) | 2023-06-07 | — | — | EP | disclosed |
| WO-2022029078-A1 | A POLYESTER MOLDING COMPRISING A METAL-ORGANIC FRAMEWORK HAVING A LOW OUTGASSING OF VOLATILE ORGANIC COMPOUNDS | BASF SE (DE) | 2022-02-10 | — | — | WO | disclosed |
| US-6365185-B1 | ORAL TABLET FOR DELIVERING BENEFICIAL AGENT TO MAMMAL COMPRISING CORE COMPARTMENT HAVING BENEFICIAL AGENT SURROUNDED BY UNITARY SELF-DESTRUCTING SHELL COMPRISING PLURALITY OF DISINTEGRANT PARTICLES DISPERSED WITHIN SEMIPERMEABLE MATRIX | UNIVERSITY OF CINCINNATI | 2002-04-02 | — | — | US | disclosed |
| EP-0929514-A1 | PROCESS FOR THE PREPARATION OF FLUOXETINE | EGIS GYOGYSZERGYAR RT. (HU) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998011054-A1 | PROCESS FOR THE PREPARATION OF FLUOXETINE | EGIS Gyógyszergyár Rt. (HU) | 1998-03-19 | — | — | WO | disclosed |
| US-3995018-A | Method of binding immunoglobulin employing a polypeptide from microorganisms | PHARMACIA AKTIEBOLAG (SW) | 1976-11-30 | — | — | US | disclosed |