SCHEMBL7713971

SCHEMBL7713971

N=C(Nc1c(F)cc(C(F)(F)F)cc1F)C(F)(F)C(F)(F)F

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 2/20 0.33
MAPT P10636 1/20 0.32
P2RX1 P51575 1/20 0.31
P2RX7 Q99572 1/20 0.31
PDE2A O00408 1/20 0.31
TLR7 Q9NYK1 1/20 0.31
CES2 O00748 1/20 0.31
KIF11 P52732 1/20 0.30
IL2 P60568 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7715450 0.89 TLR7 (0.35) GPR35MAPTTLR7IL2
SCHEMBL7716317 0.85 GPR35 (0.34) GPR35MAPTP2RX1P2RX7PDE2A
SCHEMBL7715451 0.81 GPR35 (0.36) GPR35MAPTP2RX1P2RX7PDE2A
SCHEMBL7716069 0.81 NOTUM (0.32) GPR35MAPT
SCHEMBL7713795 0.76 RAPGEF4 (0.39) GPR35MAPTPDE2A
SCHEMBL7718354 0.75 TLR7 (0.37) GPR35MAPTTLR7IL2
SCHEMBL7715485 0.74 ALDH1A1 (0.49) MAPTP2RX1
SCHEMBL7710563 0.74 ALDH1A1 (0.32) GPR35MAPT
SCHEMBL7715974 0.71 AR (0.39)
SCHEMBL7715443 0.71 GPR35 (0.34) GPR35MAPTP2RX1P2RX7PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376710-B2 INSECTICIDES, NEMATODICIDES, MITICIDES SUMITOMO CHEMICAL CO., LTD. (JP) 2002-04-23 US disclosed
US-20010041740-A1 Amidine compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2001-11-15 US disclosed
EP-1138668-A2 Amidine compounds and their use as pesticides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-10-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010041740-A1 Amidine compounds and their use as pesticides DDT, CNR1, PRMT1 GPR35 1454/4885MAPT 4801/4885P2RX1 921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.