SCHEMBL7714355

SCHEMBL7714355

Nc1ccc(-c2cc(O)c(N)c(C(F)(F)C(F)(F)F)c2)cc1O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.55
HSD17B10 Q99714 2/20 0.55
CYP3A4 P08684 1/20 0.55
BRD4 O60885 1/20 0.38
KMT2A Q03164 4/20 0.34
KDM4E B2RXH2 3/20 0.34
MEN1 O00255 3/20 0.34
GAA P10253 2/20 0.34
MAPT P10636 2/20 0.34
POLB P06746 1/20 0.34
RAB9A P51151 1/20 0.34
PPM1B O75688 1/20 0.34
GFER P55789 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
USP2 O75604 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7714350 0.89 ALDH1A1 (0.46) ALOX15HSD17B10CYP3A4KMT2AKDM4E
SCHEMBL7992614 0.88 CA1 (0.32) ALOX15HSD17B10CYP3A4KMT2AKDM4E
SCHEMBL7464743 0.87 ALOX15 (0.59) ALOX15HSD17B10CYP3A4BRD4KMT2A
SCHEMBL7719540 0.77 ALOX15 (0.50) ALOX15HSD17B10CYP3A4BRD4KMT2A
SCHEMBL8922726 0.77 TDP1 (0.44) ALOX15HSD17B10CYP3A4KMT2AKDM4E
SCHEMBL7719490 0.75 ALOX15 (0.49) ALOX15HSD17B10CYP3A4KMT2AKDM4E
SCHEMBL7718781 0.74 ALDH1A1 (0.47) ALOX15HSD17B10CYP3A4KMT2AKDM4E
SCHEMBL23924225 0.74 CYP3A4 (1.00) ALOX15HSD17B10CYP3A4BRD4KMT2A
SCHEMBL29365557 0.74 CYP3A4 (1.00) ALOX15HSD17B10CYP3A4BRD4KMT2A
SCHEMBL29549758 0.74 CYP3A4 (1.00) ALOX15HSD17B10CYP3A4BRD4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6380271-B1 MIXING A POLYBENZOXAZOLE PRECURSOR OR A POLYBENZOXAZOLE RESIN WITH AN OLIGOMER, FORMING FILM FROM RESULTING MIXTURE, HEATING FILM IN NITROGEN CONTAINING OXYGEN TO GIVE RISE TO THERMAL DECOMPOSITION AND GASIFICATION OF OLIGOMER TO FORM RESIN LAYER SUMITOMO BAKELITE COMPANY LIMITED (JP) 2002-04-30 US disclosed
US-6297351-B1 EXCELLENT IN ELECTRIC CHARACTERISTICS AND HEAT RESISTANCE, PRECURSOR FROM A DICARBOXYLIC ACID AND A BISAMINOPHENOL COMPOUND OR A DIAMINODIHYDROXY SUMITOMO BAKELITE COMPANY LIMITED (JP) 2001-10-02 US disclosed