SCHEMBL7719490

SCHEMBL7719490

Nc1cc(-c2cc(O)c(N)c(C(F)(F)F)c2)ccc1O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.49
HSD17B10 Q99714 4/20 0.49
ALDH1A1 P00352 4/20 0.49
MEN1 O00255 2/20 0.49
GAA P10253 2/20 0.49
MAPT P10636 2/20 0.49
KMT2A Q03164 2/20 0.49
HPGD P15428 2/20 0.49
ALOX12 P18054 2/20 0.49
KDM4E B2RXH2 1/20 0.49
USP2 O75604 1/20 0.49
LMNA P02545 1/20 0.49
HSP90AA1 P07900 1/20 0.49
HTT P42858 1/20 0.49
CYP3A4 P08684 1/20 0.42
HSD17B1 P14061 4/20 0.42
HSD17B2 P37059 4/20 0.42
KIF11 P52732 5/20 0.40
PPM1B O75688 1/20 0.38
AR P10275 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7464743 0.88 ALOX15 (0.59) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL7714350 0.87 ALDH1A1 (0.46) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL5669382 0.86 HSD17B1 (0.36) ALOX15HSD17B10GAACYP3A4HSD17B1
SCHEMBL7464394 0.85 HSD17B10 (0.50) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL6852473 0.83 CA1 (0.36) ALOX15HSD17B10CYP3A4HSD17B1HSD17B2
SCHEMBL7718781 0.75 ALDH1A1 (0.47) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL7714355 0.75 ALOX15 (0.55) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL108713 0.75 ALDH1A1 (0.77) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL28822417 0.75 ALDH1A1 (0.77) ALOX15HSD17B10ALDH1A1MEN1GAA
SCHEMBL29367250 0.75 ALDH1A1 (0.77) ALOX15HSD17B10ALDH1A1MEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6380271-B1 MIXING A POLYBENZOXAZOLE PRECURSOR OR A POLYBENZOXAZOLE RESIN WITH AN OLIGOMER, FORMING FILM FROM RESULTING MIXTURE, HEATING FILM IN NITROGEN CONTAINING OXYGEN TO GIVE RISE TO THERMAL DECOMPOSITION AND GASIFICATION OF OLIGOMER TO FORM RESIN LAYER SUMITOMO BAKELITE COMPANY LIMITED (JP) 2002-04-30 US disclosed
US-6297351-B1 EXCELLENT IN ELECTRIC CHARACTERISTICS AND HEAT RESISTANCE, PRECURSOR FROM A DICARBOXYLIC ACID AND A BISAMINOPHENOL COMPOUND OR A DIAMINODIHYDROXY SUMITOMO BAKELITE COMPANY LIMITED (JP) 2001-10-02 US disclosed